A big loss. The Bengals will be without their top running back on Sunday, as Joe Mixon has been ruled out with a concussion. Cincinnati announced the news on Friday afternoon. Bengals’ RB Joe Mixon ruled out for Sunday’s game vs. Tennessee due to his concussion. — Adam Schefter (@AdamSchefter) November 25, 2022 Mixon was held out of practice all week. With Mixon out, it will be Samaje Perine getting the bulk of the work on Sunday. Just two weeks ago, it was Mixon scoring five (!) touchdowns against the Panthers. This is a significant loss for Cincinnati. Mixon has…