Week 2 2026 bold predictions: Giants to upset Rams, tanking Dolphins cover against 49ers

Evan Bernstein/Getty Images The NFL never fails to surprise, despite so many entering a new season thinking they know what’s going to happen. Just take a look at Week 1. No one had the Arizona Cardinals upsetting the Los Angeles Chargers 26-14 on the road, and almost no one had the preseason Super Bowl favorite Los Angeles Rams getting smoked in Australia by the San Francisco 49ers, 27-7. To kick off Week 2, the Buffalo Bills thumped the Detroit Lions 41-31 in a game in which they led 21-0. Not a bad way to open their new home at Highmark…